5 BlaKPC-2 and blaKPC-3 are the most common KPC gene variants globally, which has a high prevalence in Europe (Italy, Greece) and the Middle East (Israel). 4 So far, 102 different variants have been reported in the KPC family ( ), distributed in more than 115 ST-typed Klebsiella pneumoniae. The transmission of blaKPC involves multiple mechanisms of transfer from plasmid level to blaKPC gene clone transmission. 2, 3 KPC is one of the main carbapenem enzymes encoded by blaKPC gene variants. ![]() 1 Since the first strain of Klebsiella pneumoniae producing a class A carbapenem enzyme was found in the United States in 1996, the KPC enzyme has spread rapidly worldwide and aroused great public concern. ![]() As one of the most common gram-negative bacteria, Klebsiella pneumoniae can cause various nosocomial infections.
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